In MADE REACT, 23 companies and experts from five Danish universities and three RTOs will collaborate to explore AI, digital twins, advanced robotics, and real-time data-driven decision-making. REACT will focus on manufacturing challenges inside the manufacturing ecosystem divided into Factory-, Cell and Process level. A coordinated set of research activities will be initiated within these levels in combination with digital research going across all levels. Demonstration environments around the three levels will be established. These will enable integration of research results in realistic scenarios, and will increase visibility, facilitate dissemination and hence enhance impact. By this, MADE REACT will enable Danish manufacturing to be the most efficient in the world for the Resilient High-Mix